Join us for the Autumn Series
of the Wright Fleming Institute (hybrid) Seminars
Dr Leo Swadling
Biography
Dr Leo Swadling isÌýa new group leaderÌýand Advancement Fellow (Rosetrees Trust/Pears Foundation) in the Infection and Immunity division at UCL. He obtained his PhD from the University of Oxford, developingÌýgenetic and molecular technologies to optimise vaccines for viral hepatitisÌýwith Profs Ellie Barnes and Paul Klenerman. He moved to London to studyÌýliver-resident T cells with Professor Mala Maini and during the pandemic hasÌýswitched his focus to characterising T cell responses to SARS-CoV-2 as part of the UK-Coronavirus immunology consortium () and COVIDsortium ().Ìý
Overall theirÌýresearchÌýaims to establishÌýT cell correlates of protectionÌýbyÌýintegrating high-resolution single-cell studies of T cell quality (function, phenotype, trafficking) and specificity (virus, protein, epitope, TCR clonality) at the extremes ofÌýcontrolled or uncontrolled viral infections, andÌýto design vaccines to recapitulate and test these correlates.Ìý
The talk will focus on their work contrasting T cell specificity in the context of abortive and laboratory confirmed SARS-CoV-2 infection in a prospective health care worker study, in particular the influence of pre-existing T cells targeting the highly conserved replication-transcription complex on outcome to viral exposure. Further info: Ìý Ìý
Join in person at the St Mary’s Campus, Medical School Building, Roger Bannister Lecture Theatre, 1st Floor or
on your computer, mobile app or room device
Meeting ID:Ìý356 829 473 417
Passcode:Ìý7B9JVB
