Microbial populations constantly adapt to changing environments, and chemical treatments select for resistant variants, driving antimicrobial resistance. While bacterial resistance is well known, antifungal resistance, particularly in Aspergillus species such as A. fumigatus, is an under-recognised threat to crop protection and human health. The use of azole fungicides in agriculture mirrors frontline clinical treatments and promotes azole-resistant A. fumigatus in nature.
This project investigates how agricultural practices and green-waste recycling create environmental hotspots of resistance, using field and lab studies, spatially explicit Bayesian models, and systems network analysis to predict, understand, and mitigate fungal resistance within a One Health framework. ERGs Emerging Chemical Contaminants team contribute to this project through the development and application of new 3D-printed passive samplers for the detection and monitoring of antifungal agents and their transformation products in compost and soil using mass spectrometry.
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