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• Journal article
  Rowlands CJ, Park D, Bruns OT, Piatkevich KD, Fukumura D, Jain RK, Bawendi MG, Boyden ES, So PTCet al., 2017,
  , Light: Science and Applications, Vol: 6, Pages: 1-9, ISSN: 2047-7538

  Three-photon wide-field depth-resolved excitation is used to overcome some of the limitations in conventional point-scanning two- and three-photon microscopy. Excitation of chromophores as diverse as channelrhodopsins and quantum dots is shown, and a penetration depth of more than 700 μm into fixed scattering brain tissue is achieved, approximately twice as deep as that achieved using two-photon wide-field excitation. Compatibility with live animal experiments is confirmed by imaging the cerebral vasculature of an anesthetized mouse; a complete focal stack was obtained without any evidence of photodamage. As an additional validation of the utility of wide-field three-photon excitation, functional excitation is demonstrated by performing three-photon optogenetic stimulation of cultured mouse hippocampal neurons expressing a channelrhodopsin; action potentials could reliably be excited without causing photodamage.

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• Journal article
  Bruns OT, Bischof TS, Harris DK, Franke D, Shi Y, Riedemann L, Bartelt A, Jaworski FB, Carr JA, Rowlands CJ, Wilson MWB, Chen O, Wei H, Hwang GW, Montana DM, Coropceanu I, Achorn OB, Kloepper J, Heeren J, So PTC, Fukumura D, Jensen KF, Jain RK, Bawendi MGet al., 2017,
  , NATURE BIOMEDICAL ENGINEERING, Vol: 1, ISSN: 2157-846X
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• Journal article
  Abshire JR, Rowlands CJ, Ganesan SM, So PTC, Niles JCet al., 2017,
  , PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 114, Pages: E2068-E2076, ISSN: 0027-8424
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• Journal article
  Park JK, Rowlands CJ, So PTC, 2017,
  , MICROMACHINES, Vol: 8, ISSN: 2072-666X
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• Journal article
  Uzel SGM, Platt RJ, Subramanian V, Pearl TM, Rowlands CJ, Chan V, Boyer LA, So PTC, Kamm RDet al., 2016,
  , SCIENCE ADVANCES, Vol: 2, ISSN: 2375-2548
  • Cite
  • Citations: 144
• Conference paper
  Rowlands CJ, Bruns OT, Franke D, Bawendi MG, So PTCet al., 2016,

  The tissue penetration depth of temporal focusing is increased by utilizing longer excitation wavelengths combined with quantum dots possessing extremely high two-photon crosssections. Cerebral vasculature is imaged in a mouse brain in vivo.

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• Book chapter
  So PTC, Yew E, Rowlands C, 2016,
  , IMAGING IN DERMATOLOGY, Editors: Hamblin, Avci, Gupta, Publisher: ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD, Pages: 241-268, ISBN: 978-0-12-802838-4
  • Cite
  • Citations: 2
• Journal article
  Rowlands CJ, Bruns OT, Bawendi MG, So PTCet al., 2015,
  , JOURNAL OF BIOMEDICAL OPTICS, Vol: 20, ISSN: 1083-3668
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  • Citations: 7
• Conference paper
  Xue Y, Rowlands CJ, So PTC, 2015,
  , Conference on Multiphoton Microscopy in the Biomedical Sciences XV, Publisher: SPIE-INT SOC OPTICAL ENGINEERING, ISSN: 0277-786X
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  • Citations: 3
• Journal article
  Rowlands CJ, Wu J, Uzel SGM, Klein O, Evans CL, So PTCet al., 2014,
  , Laser Physics Letters, Vol: 11, ISSN: 1612-2011

  A method for selectively inducing apoptosis in tumor nodules is presented, with close-to-cellular level resolution, using 3D-resolved widefield temporal focusing illumination. Treatment times on the order of seconds were achieved using Verteporfin as the photosensitizer, with doses of 30 μg ml−1 and below. Results were achieved on both 2D and 3D cell cultures, demonstrating that treatment was possible through approximately one hundred microns of dense tumor nodules.

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• Journal article
  Kong K, Rowlands CJ, Varma S, Perkins W, Leach IH, Koloydenko AA, Pitiot A, Williams HC, Notingher Iet al., 2014,
  , JOURNAL OF MOLECULAR STRUCTURE, Vol: 1073, Pages: 58-65, ISSN: 0022-2860
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  • Citations: 10
• Journal article
  Yew E, Rowlands C, So PTC, 2014,
  , JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES, Vol: 7, ISSN: 1793-5458
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  • Citations: 55
• Journal article
  So PTC, Yew EYS, Rowlands C, 2013,
  , BIOPHYSICAL JOURNAL, Vol: 105, Pages: 2641-2654, ISSN: 0006-3495
  • Cite
  • Citations: 31
• Journal article
  Kong K, Rowlands CJ, Varma S, Perkins W, Leach IH, Koloydenko AA, Williams HC, Notingher Iet al., 2013,
  , PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 110, Pages: 15189-15194, ISSN: 0027-8424
  • Cite
  • Citations: 179
• Journal article
  Rowlands CJ, Yew EYS, So PTC, 2013,
  , NATURE METHODS, Vol: 10, Pages: 709-710, ISSN: 1548-7091
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  • Citations: 2
• Journal article
  Rowlands CJ, So PTC, 2013,
  , APPLIED PHYSICS LETTERS, Vol: 102, ISSN: 0003-6951
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  • Citations: 9
• Journal article
  Rowlands CJ, Varma S, Perkins W, Leach I, Williams H, Notingher Iet al., 2012,
  , JOURNAL OF BIOPHOTONICS, Vol: 5, Pages: 220-229, ISSN: 1864-063X
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  • Citations: 37
• Conference paper
  Rowlands CJ, Notingher I, 2012,

  We present a new method for selectively sampling hyperspectral Raman maps in order to maximize the information that can be obtained for a given sample time. Example maps and comparisons with alternative methods are provided. © OSA 2012.

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• Journal article
  Kong K, Rowlands CJ, Elsheikha H, Notingher Iet al., 2012,
  , ANALYST, Vol: 137, Pages: 4119-4122, ISSN: 0003-2654
  • Cite
  • Citations: 17
• Journal article
  Rowlands CJ, Elliott SR, 2011,
  , JOURNAL OF RAMAN SPECTROSCOPY, Vol: 42, Pages: 1761-1768, ISSN: 0377-0486
  • Cite
  • Citations: 7

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