BibTex format
@article{Burney:2026,
author = {Burney, P and Bagkeris, E and Potts, J and Nielsen, R and Devereux, G and El, Rhazi K and Aquart-Stewart, A and Nafees, A and Koul, P and Mahesh, P and Agarwal, D and Juvekar, S and Gislason, T and Denguezli, M and Harrabi, I and Paraguas, S and Jogi, R and Erhabor, G and Buist, AS and Janson, C and Amaral, A},
journal = {International Journal of Epidemiology},
title = {A cohort study of forced vital capacity, airway obstruction and survival in the multinational Burden of Obstructive Lung Disease (BOLD) study},
year = {2026}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - BackgroundIn the USA, higher forced vital capacity (FVC) is linked with longer survival, and FVC is associated with survival independently of ethnicity. The implications for the low FVC values in parts of Asia and Africa are unknown.MethodsWe used data from 16 sites of the multinational Burden of Obstructive Lung Disease (BOLD) study that completed follow-up of participants between 2019 and 2021 and reported at least five deaths between baseline and follow-up. We assessed the association between mortality and FVC and one-second Forced Expiratory Volume (FEV1)/FVC ratio within each site using Cox proportional hazards models. These models were adjusted for age, smoking, height and weight. Effect estimates from all sites were combined using meta-analysis. Systematic regional differences were investigated.ResultsOf 9,927 study participants with follow-up data, 1,120 (11.3%) had died (mean follow-up = 8.7 years, standard deviation (SD) = 3.3 years). Baseline post-bronchodilator FVC and FEV1/FVC were inversely associated with mortality. When both FVC and FEV1/FVC were mutually adjusted for each other, the decreased mortality rates were more pronounced for each standard deviation higher FVC at baseline (44% (95% confidence interval (CI): 25%, 58%) for men and 28% (95%CI: 11%, 41%) for women) than for FEV1/FVC at baseline (14% (95% CI: 8%, 20%) for men and 7% (95% -10%, 21%) for women). The probability of true regional differences was low.ConclusionsPeople with a higher FVC adjusted for age, sex and height have a longer survival. Regional adjustments to lung function standards are inappropriate when assessing prognosis.
AU - Burney,P
AU - Bagkeris,E
AU - Potts,J
AU - Nielsen,R
AU - Devereux,G
AU - El,Rhazi K
AU - Aquart-Stewart,A
AU - Nafees,A
AU - Koul,P
AU - Mahesh,P
AU - Agarwal,D
AU - Juvekar,S
AU - Gislason,T
AU - Denguezli,M
AU - Harrabi,I
AU - Paraguas,S
AU - Jogi,R
AU - Erhabor,G
AU - Buist,AS
AU - Janson,C
AU - Amaral,A
PY - 2026///
SN - 0300-5771
TI - A cohort study of forced vital capacity, airway obstruction and survival in the multinational Burden of Obstructive Lung Disease (BOLD) study
T2 - International Journal of Epidemiology
ER -
