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Our latest Nature Chemical Biology News & Views article highlights new strategies that could expand the discovery of molecular glues for targeted protein degradation.

In , we discuss two recent studies that used target-focused chemical approaches to identify previously unrecognised E3 ligases that can be recruited for protein degradation. These studies demonstrate how high-throughput chemistry and covalent prodrug design can help uncover new molecular glue mechanisms and broaden the range of proteins that may be therapeutically targeted.

By moving beyond the small number of E3 ligases currently used in the field, these findings offer new opportunities to develop more versatile targeted protein degradation strategies and further expand the molecular glue toolbox.

Congratulations to Dr Janine Gray and Dr Zhangping Xiao on this publication!