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• Journal article
  Uhm S, Alderdice F, Chambers B, Gyte G, Gale C, Duley L, James C, David A, McNeill J, Turner M, Shennan A, Deshpande S, Crowe S, Chivers Z, Brady I, Oliver Set al., 2014,
  , Arch Dis Child Fetal Neonatal Ed, Vol: 99 Suppl 1

  Preterm birth is the single most important determinant of adverse infant outcomes in terms of survival, quality of life, psychosocial and emotional impact on the family, and health care costs. Research agenda in this area has been determined primarily by researchers, and the processes for priority setting in research have often lacked transparency.

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• Journal article
  Gale C, Santhakumaran S, Wells J, Modi Net al., 2014,
  , Arch Dis Child Fetal Neonatal Ed, Vol: 99 Suppl 1, Pages: A40-A41

  Direct measurement of adipose tissue using magnetic resonance imaging (MRI) is increasingly used to characterise body composition. Optimal techniques for adjusting direct measures of infant adipose tissue remain to be determined.

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• Journal article
  Darmasseelane K, Hyde MJ, Santhakumaran S, Gale C, Modi Net al., 2014,
  , PLOS ONE, Vol: 9, ISSN: 1932-6203
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• Journal article
  Gale C, Thomas EL, Jeffries S, Durighel G, Logan KM, Parkinson JRC, Uthaya S, Santhakumaran S, Bell JD, Modi Net al., 2014,
  , American Journal of Clinical Nutrition, Vol: 99, Pages: 1034-1040, ISSN: 0002-9165

  Background: The effect of mode of infant feeding on adiposity deposition is not fully understood.Objective: The objective was to test the hypothesis that differences in total and regional adipose tissue content and intrahepatocellular lipid (IHCL) arise in early infancy between breast- and formula-fed infants and to describe longitudinal changes.Design: This prospective longitudinal cohort study was performed in 2 hospitals in the United Kingdom. Healthy, full-term, appropriate weight-for-gestational age infants were recruited; adipose tissue volume and distribution were directly quantified by using whole-body magnetic resonance imaging; IHCL was assessed by in vivo proton magnetic resonance spectroscopy. Measurements were performed after birth (median age: 13 d) and at 6–12 wk of age. Method of infant feeding was recorded prospectively by using maternally completed feeding diaries. Breastfed was defined as >80% of feeds consisting of breast milk at both points; formula-fed was defined as >80% of feeds consisting of formula milk at both points.Results: Longitudinal results were obtained from 70 infants (36 breastfed, 9 mixed-fed, and 25 formula-fed). No differences were found in total or regional adipose tissue or IHCL between breastfed and formula-fed infants. In pooled analyses including all feeding groups, IHCL and total adipose tissue approximately doubled between birth and 6–12 wk: IHCL after birth (median: 0.949; IQR: 0.521–1.711) and at 6–12 wk (1.828; 1.376–2.697; P < 0.001) and total adipose tissue after birth (0.749 L; 0.620–0.928 L) and at 6–12 wk (1.547 L; 1.332–1.790 L; P < 0.001). Increasing adiposity was characterized by greater relative increases in subcutaneous than in internal adipose tissue depots.Conclusions: No differences were detectable in adipose tissue or IHCL accretion between breastfed and formula-fed infants up to 2 mo. The substantial increase in IHCL seen over this period in bo

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• Journal article
  Wong HS, Santhakumaran S, Statnikov Y, Gray D, Watkinson M, Modi Net al., 2014,
  , ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION, Vol: 99, Pages: F196-F202, ISSN: 1359-2998
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  • Citations: 18
• Journal article
  Gale C, Santhakumaran S, Wells JCK, Modi Net al., 2014,
  , International Journal of Obesity, Vol: 38, Pages: 995-999, ISSN: 1476-5497
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• Journal article
  Shah PS, Lee SK, Lui K, Sjors G, Mori R, Reichman B, Hakansson S, Feliciano LS, Modi N, Adams M, Darlow B, Fujimura M, Kusuda S, Haslam R, Mirea Let al., 2014,
  , BMC PEDIATRICS, Vol: 14
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  • Citations: 67
• Journal article
  Darmasseelane K, Hyde MJ, Santhakumaran S, Gale C, Modi Net al., 2014,
  , PLOS One, Vol: 9, ISSN: 1932-6203
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• Journal article
  Thangarajah D, Chappell KE, Gale C, Parkinson JR, Epstein J, Hyer W, Soondrum K, Frost G, Fell JMet al., 2014,
  , JOURNAL OF CROHNS & COLITIS, Vol: 8, Pages: S239-S239, ISSN: 1873-9946
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  • Citations: 3
• Journal article
  Wong HS, Huertas-Ceballos A, Cowan FM, Modi Net al., 2014,
  , JOURNAL OF PEDIATRICS, Vol: 164, Pages: 26-+, ISSN: 0022-3476
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  • Citations: 46

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