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  • Journal article
    Venkatesh M, Mukherjee S, Wang H, Li H, Sun K, Benechet AP, Qiu Z, Maher L, Redinbo MR, Phillips RS, Fleet JC, Kortagere S, Mukherjee P, Fasano A, Le Ven J, Nicholson JK, Dumas ME, Khanna KM, Mani Set al., 2014,

    , Immunity, Vol: 41, Pages: 296-310, ISSN: 1074-7613

    Intestinal microbial metabolites are conjectured to affect mucosal integrity through an incompletely characterized mechanism. Here we showed that microbial-specific indoles regulated intestinal barrier function through the xenobiotic sensor, pregnane X receptor (PXR). Indole 3-propionic acid (IPA), in the context of indole, is a ligand for PXR in vivo, and IPA downregulated enterocyte TNF-α while it upregulated junctional protein-coding mRNAs. PXR-deficient (Nr1i2−/−) mice showed a distinctly “leaky” gut physiology coupled with upregulation of the Toll-like receptor (TLR) signaling pathway. These defects in the epithelial barrier were corrected in Nr1i2−/−Tlr4−/− mice. Our results demonstrate that a direct chemical communication between the intestinal symbionts and PXR regulates mucosal integrity through a pathway that involves luminal sensing and signaling by TLR4.
  • Patent
    Martin FP, Boulange CL, Montoliu Roura I, Collino S, Dumas ME, Holmes E, Rezzi SAD, Nicholson JK, Kochhar Set al., 2014,

    Trimethylamine-N-oxide as biomarker for the predisposition for weight gain and obesity

    , WO2014086604

    The present invention relates generally to the field of nutrition and health. In particular, the present invention relates to a new biomarker, its use and a nnethod that allows it to diagnose the likelihood to resist diet induced weight gain, and/or to be susceptible to a diet induced weight gain. For example, the biomarker may be trimethylamine-N-oxide.
  • Patent
    Martin FP, BOULANGE CL, MONTOLIU ROURA I, COLLINO S, Dumas ME, HOLMES E, REZZI SAD, NICHOLSON JK, KOCHHAR Set al., 2014,

    Isovalerylglycine as biomarker for the predisposition for weight gain and obesity

    , WO2014086605

    The present invention relates generally to the field of nutrition and health. In particular, the present invention relates to a new biomarker, its use and a method that allows it to diagnose the likelihood to resist diet induced weight gain, and/or to be susceptible to a diet induced weight gain. For example, the biomarker may be isovalerylglycine.
  • Patent
    MARTIN FP, Boulange CL, Montoliu Roura I, COLLINO S, Dumas ME, Holmes E, REZZI SAD, Nicholson JK, Kochhar Set al., 2014,

    Hexanoylglycine as biomarker for the predisposition for weight gain and obesity

    , WO 2014/086603

    The present invention relates generally to the field of nutrition and health. In particular, the present invention relates to a new biomarker, its use and a method that allows it to diagnose the likelihood to resist diet induced weight gain, and/or to be susceptible to a diet induced weight gain. For example, the biomarker may be hexanoylglycine.
  • Journal article
    Dumas M-E, Kinross J, Nicholson JK, 2014,

    , GASTROENTEROLOGY, Vol: 146, Pages: 46-62, ISSN: 0016-5085
    • Cite
    • Citations: 142
  • Journal article
    Molyneaux PL, Mallia P, Cox MJ, Footitt J, Willis-Owen SAG, Homola D, Trujillo-Torralbo M-B, Elkin S, Kon OM, Cookson WOC, Moffatt MF, Johnston SLet al., 2013,

    , AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 188, Pages: 1224-1231, ISSN: 1073-449X
    • Cite
    • Citations: 296
  • Journal article
    Cox MJ, Cookson WOCM, Moffatt MF, 2013,

    , HUMAN MOLECULAR GENETICS, Vol: 22, Pages: R88-R94, ISSN: 0964-6906
    • Cite
    • Citations: 101
  • Journal article
    Russell WR, Hoyles L, Flint HJ, Dumas MEet al., 2013,

    , Current Opinion in Microbiology

    The influence of the microbial–mammalian metabolic axis is becoming increasingly important for human health. Bacterial fermentation of carbohydrates (CHOs) and proteins produces short-chain fatty acids (SCFA) and a range of other metabolites including those from aromatic amino acid (AAA) fermentation. SCFA influence host health as energy sources and via multiple signalling mechanisms. Bacterial transformation of fibre-related phytochemicals is associated with a reduced incidence of several chronic diseases. The ‘gut–liver axis’ is an emerging area of study. Microbial deconjugation of xenobiotics and release of aromatic moieties into the colon can have a wide range of physiological consequences. In addition, the role of the gut microbiota in choline deficiency in non-alcoholic fatty liver disease (NAFLD) and insulin resistance is receiving increased attention.
  • Journal article
    Duff RM, Simmonds NJ, Davies JC, Wilson R, Alton EW, Pantelidis P, Cox MJ, Cookson WOCM, Bilton D, Moffatt MFet al., 2013,

    , EUROPEAN RESPIRATORY JOURNAL, Vol: 41, Pages: 991-993, ISSN: 0903-1936
    • Cite
    • Citations: 13
  • Journal article
    Cardenas PA, Cooper PJ, Cox MJ, Chico M, Arias C, Moffatt MF, Cookson WOet al., 2012,

    , PLOS ONE, Vol: 7, ISSN: 1932-6203
    • Cite
    • Citations: 83

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