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Project information
Transmission-blocking vaccines aim to prevent malaria transmission from an infected human to a feeding Anopheles mosquito. At present, these vaccines are primarily evaluated in the laboratory, using membrane feeding assays. We are developing mathematical models to translate a lab-evaluated vaccine efficacy into a predicted efficacy in the field. Using this translation, we can then use modelling to predict the public health impact of a transmission-blocking vaccine in different settings in Africa. The work will identify areas where such a vaccine is likely to save the most lives, and how the vaccine could best complement other public health interventions against malaria . Furthermore, the group鈥檚 research into the infectious reservoir - e.g. which age groups contribute the most to transmission - will inform our assessment of key age groups to vaccinate. These models shall also be used to help design clinical trials to evaluate the interventions in the field.
Recent publications
J. D. Challenger, D. Olivera Mesa, D. F. Da, R. S. Yerbanga, T. Lef猫vre, A. Cohuet and T. S. Churcher: . Nature Communications (2021)
Sherrard-Smith E, Sala KA, Betancourt M, Upton LM, Angrisano F, Morin MJ, Ghani AC, Churcher TS, Blagborough AM (2018) . eLife doi: 10.7554/eLife.35213. PMID: 29914622; PMCID: PMC6008048.
Churcher TS, Bousema T, Walker M, Drakeley C, Schneider P, Ouedraogo AL, Basanez M-Get al., 2013, , ELIFE, Vol: 2, ISSN: 2050-084X .