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@article{Saber:2026:10.1038/s41467-026-72938-z,
author = {Saber, SH and Yak, N and Dolski, K and M盲ki, S and Levanov, L and Willenbrink, LA and Sng, JDJ and Shaker, MR and Morrison, SD and Zheng, H and Pars, S and Pietrogrande, G and Bong, YT and Vane-Tempest, T and Smura, T and Strandin, T and Ojha, R and Kant, R and Ruuska, J and Topi, F and Vaskiv, D and Kareinen, L and Binder, T and Lu, S and Floetenmeyer, M and Al-Mhanawi, B and Zhu, Y and Sironen, T and Talbo, GH and Short, KR and Kallemeijn, WW and Solari, R and Mar, J and Tate, EW and van, Waardenberg AJ and Vapalahti, O and Wolvetang, E and Balistreri, G and Joensuu, M},
doi = {10.1038/s41467-026-72938-z},
journal = {Nat Commun},
title = {Inhibition of host N-myristoylation compromises the infectivity of SARS-CoV-2 due to Golgi-bypassing egress.},
url = {http://dx.doi.org/10.1038/s41467-026-72938-z},
year = {2026}
}
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TY  - JOUR
AB  - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which caused the coronavirus disease 2019 (COVID-19) pandemic, remains a global health concern despite vaccines, neutralizing antibodies, and antiviral drugs. The emergence of viral mutations that diminish the effectiveness of current interventions underscores the importance of alternative, host-directed strategies. Here, we show that pharmacological inhibition or knockdown of host N-myristoyltransferase 1 (NMT1), one of the two human enzymes that mediates protein N-myristoylation, significantly impairs SARS-CoV-2, Vesicular Stomatitis Virus (VSV) and Respiratory syncytial virus (RSV) infections. We demonstrate the antiviral efficacy and safety of this host-directed therapeutic strategy across multiple viral tropic sites, including human lung adenocarcinoma cell lines, primary nasal epithelial cells, and human choroid plexus-cortical brain organoids. NMT1 inhibition triggers a Golgi-bypassing pathway for SARS-CoV-2 progeny virion egress, through endoplasmic reticulum and lysosomal structures, which leads to perturbed progeny virion composition and spike maturation, impairing progeny virion infectivity.
AU  - Saber,SH
AU  - Yak,N
AU  - Dolski,K
AU  - M盲ki,S
AU  - Levanov,L
AU  - Willenbrink,LA
AU  - Sng,JDJ
AU  - Shaker,MR
AU  - Morrison,SD
AU  - Zheng,H
AU  - Pars,S
AU  - Pietrogrande,G
AU  - Bong,YT
AU  - Vane-Tempest,T
AU  - Smura,T
AU  - Strandin,T
AU  - Ojha,R
AU  - Kant,R
AU  - Ruuska,J
AU  - Topi,F
AU  - Vaskiv,D
AU  - Kareinen,L
AU  - Binder,T
AU  - Lu,S
AU  - Floetenmeyer,M
AU  - Al-Mhanawi,B
AU  - Zhu,Y
AU  - Sironen,T
AU  - Talbo,GH
AU  - Short,KR
AU  - Kallemeijn,WW
AU  - Solari,R
AU  - Mar,J
AU  - Tate,EW
AU  - van,Waardenberg AJ
AU  - Vapalahti,O
AU  - Wolvetang,E
AU  - Balistreri,G
AU  - Joensuu,M
DO  - 10.1038/s41467-026-72938-z
PY  - 2026///
TI  - Inhibition of host N-myristoylation compromises the infectivity of SARS-CoV-2 due to Golgi-bypassing egress.
T2  - Nat Commun
UR  - http://dx.doi.org/10.1038/s41467-026-72938-z
UR  - https://www.ncbi.nlm.nih.gov/pubmed/42115621
ER  -
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